ea0059p176 | Obesity & metabolism | SFEBES2018
Garten Antje
, Cartwright David
, Oakey Lucy
, Fletcher Rachel
, Nasteska Daniela
, Hodson David
, Larner Dean
, Doig Craig
, Ludwig Christian
, Kluckova Katarina
, Lavery Gareth
Background and Aim: Supplementation with precursors of nicotinamide adenine dinucleotide (NAD), was shown to be beneficial in preventing metabolic dysfunction in mice, which is induced by feeding a high fat diet. We compared the effect of nicotinamide riboside (NR) supplementationon whole-body energy metabolism and mitochondrial function in two widely used diet-induced obesity mouse models.Methods: Mice were fed a high fat diet (HFD, 60% fat) or standard...